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Anti-Adrenomedullin Antibody

Rabbit polyclonal antibody to Adrenomedullin

     
  • WB - Anti-Adrenomedullin Antibody AP59960
    Western blot analysis of Adrenomedullin expression in mouse lung (A), mouse kidney (B) whole cell lysates.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IP
Primary Accession P35318
Reactivity Human, Mouse, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 20420 Da
Additional Information
Gene ID 133
Other Names AM; ADM
Target/Specificity Recognizes endogenous levels of Adrenomedullin protein.
Dilution WB~~WB (1/500 - 1/1000), IP (1/10 - 1/100)
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ADM (HGNC:259)
Synonyms AM
Function Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Cellular Location Secreted.
Tissue Location Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues
Research Areas
Citations (0)
citation

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Background

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Adrenomedullin. The exact sequence is proprietary.

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$ 350.00
$ 175.00
Cat# AP59960
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