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Anti-NHE5 Antibody
Rabbit polyclonal antibody to NHE5
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- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q14940 |
| Reactivity | Human, Mouse, Rat, Monkey, Pig, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 99011 Da |
| Gene ID | 6553 |
|---|---|
| Other Names | NHE5; Sodium/hydrogen exchanger 5; Na(+)/H(+) exchanger 5; NHE-5; Solute carrier family 9 member 5 |
| Target/Specificity | Recognizes endogenous levels of NHE5 protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SLC9A5 (HGNC:11078) |
|---|---|
| Synonyms | NHE5 |
| Function | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:10692428, PubMed:19276089, PubMed:24936055, PubMed:9933641). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:21551074, PubMed:24006492). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Synaptic cell membrane; Multi-pass membrane protein. Cell junction, focal adhesion. Note=Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3- kinase (PIK3CA) and SCAMP2. |
| Tissue Location | Mainly expressed in brain (PubMed:7759094, PubMed:9933641). Expressed in neurons of the central and peripheral nervous system (PubMed:21551074, PubMed:9933641). Expressed also in testis, spleen, and skeletal muscle (PubMed:7759094) |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NHE5. The exact sequence is proprietary.
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$ 385.00
$ 195.00
Cat# AP59936
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