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Anti-SENP3 Antibody
Rabbit polyclonal antibody to SENP3
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- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9H4L4 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65010 Da |
| Gene ID | 26168 |
|---|---|
| Other Names | SSP3; SUSP3; Sentrin-specific protease 3; SUMO-1-specific protease 3; Sentrin/SUMO-specific protease SENP3 |
| Target/Specificity | Recognizes endogenous levels of SENP3 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SENP3 |
|---|---|
| Function | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm {ECO:0000250|UniProtKB:Q9EP97} Note=Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). {ECO:0000250|UniProtKB:Q9EP97, ECO:0000269|PubMed:19680224} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human SENP3. The exact sequence is proprietary.
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$ 385.00
$ 195.00
Cat# AP59827
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