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Anti-NKX2-1 Antibody
Rabbit polyclonal antibody to NKX2-1
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P43699 |
| Other Accession | P50220 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, SARS, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38596 Da |
| Gene ID | 7080 |
|---|---|
| Other Names | NKX2A; TITF1; TTF1; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1 |
| Target/Specificity | Recognizes endogenous levels of NKX2-1 protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | NKX2-1 (HGNC:11825) |
|---|---|
| Synonyms | NKX2A, TITF1, TTF1 |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P50220}. |
| Tissue Location | Thyroid and lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NKX2-1. The exact sequence is proprietary.
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