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Anti-Calnexin (pS583) Antibody
Rabbit polyclonal antibody to Calnexin (pS583)
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- CITATIONS
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- BACKGROUND
Application 
| WB, IP, IF/IC, IHC |
|---|---|
| Primary Accession | P27824 |
| Other Accession | P35564 |
| Reactivity | Human, Mouse, Rat, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67568 Da |
| Gene ID | 821 |
|---|---|
| Other Names | Calnexin; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90 |
| Target/Specificity | Recognizes endogenous levels of Calnexin (pS583) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500), IP (1/10 - 1/100) IF~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500), IP (1/10 - 1/100) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CANX |
|---|---|
| Function | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:P24643}; Single-pass type I membrane protein. Melanosome membrane; Single-pass type I membrane protein. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232) Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria (By similarity). {ECO:0000250|UniProtKB:P24643, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:22314232} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Calnexin. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP59498
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