SHPRH Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, E |
---|---|
Primary Accession | Q149N8 |
Reactivity | Rat, Pig, Dog, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 193079 Da |
Gene ID | 257218 |
---|---|
Other Names | E3 ubiquitin-protein ligase SHPRH, 2.3.2.27, 3.6.4.-, RING-type E3 ubiquitin transferase SHPRH, SNF2, histone-linker, PHD and RING finger domain-containing helicase, SHPRH, KIAA2023 |
Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | SHPRH |
---|---|
Synonyms | KIAA2023 |
Function | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'. |
Tissue Location | Broadly expressed.. |
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