LETMD1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, E |
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Primary Accession | Q6P1Q0 |
Reactivity | Rat, Dog, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 41790 Da |
Gene ID | 25875 |
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Other Names | LETM1 domain-containing protein 1, Cervical cancer 1 proto-oncogene protein p40, Cervical cancer proto-oncogene 2 protein, HCCR-1, HCRR-2, LETMD1 |
Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | LETMD1 (HGNC:24241) |
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Function | Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed:31980577). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013). |
Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein. Nucleus {ECO:0000250|UniProtKB:Q924L1}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q924L1}; Single-pass membrane protein |
Tissue Location | Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix. |
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