PSMA8 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | Q8TAA3 |
Reactivity | Rat, Pig, Cynomolgus, Dog, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 28530 Da |
Gene ID | 143471 |
---|---|
Other Names | Proteasome subunit alpha-type 8, Proteasome alpha 4 subunit, Proteasome subunit alpha-type 7-like, PSMA8, PSMA7L |
Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500 |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | PSMA8 |
---|---|
Synonyms | PSMA7L |
Function | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9CWH6}. Note=Localizes to the central region of the synaptonemal complex {ECO:0000250|UniProtKB:Q9CWH6} |
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