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IKZF3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UKT9 |
| Other Accession | A2VDW9, NP_036613.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58023 Da |
| Antigen Region | 76-103 aa |
| Gene ID | 22806 |
|---|---|
| Other Names | Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3 |
| Target/Specificity | This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IKZF3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IKZF3 |
|---|---|
| Synonyms | ZNFN1A3 |
| Function | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. |
| Cellular Location | Nucleus. Cytoplasm [Isoform 3]: Nucleus [Isoform 14]: Nucleus. Cytoplasm |
| Tissue Location | Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
References
Billot, K., et al. Leuk. Res. 34(3):289-293(2010)
Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
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