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MTCH2 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MTCH2 Antibody (N-term) AP5492a
    MTCH2 Antibody (N-term) (Cat.#AP5492a) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the MTCH2 antibody detected the MTCH2 protein (arrow).
    detail
  • WB - MTCH2 Antibody (N-term) AP5492a
    MTCH2 Antibody (N-term) (Cat.#AP5492a) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the MTCH2 antibody detected the MTCH2 protein (arrow).
    detail
  • IHC-P - MTCH2 Antibody (N-term) AP5492a
    MTCH2 Antibody (N-term) (Cat. #AP5492a) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MTCH2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
  • CITATIONS: 1
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9Y6C9
Other Accession NP_055157.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33331 Da
Antigen Region 75-103 aa
Additional Information
Gene ID 23788
Other Names Mitochondrial carrier homolog 2, Met-induced mitochondrial protein, MTCH2, MIMP
Target/Specificity This MTCH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-103 amino acids from the N-terminal region of human MTCH2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMTCH2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTCH2 {ECO:0000303|PubMed:36264797, ECO:0000312|HGNC:HGNC:17587}
Function Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity).
Cellular Location Mitochondrion outer membrane; Multi-pass membrane protein
Research Areas
Citations ( 0 )

Background

The substrate transported is not yet known. It induces mitochondrial depolarization.

References

Ng, M.C., et al. J. Clin. Endocrinol. Metab. (2010)
He, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(2):327-332(2010)
Li, S., et al. Am. J. Clin. Nutr. 91(1):184-190(2010)

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$ 365.00
$ 140.00
Cat# AP5492a
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