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CD69 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q07108 |
| Other Accession | NP_001772.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22559 Da |
| Antigen Region | 119-148 aa |
| Gene ID | 969 |
|---|---|
| Other Names | Early activation antigen CD69, Activation inducer molecule, AIM, BL-AC/P26, C-type lectin domain family 2 member C, EA1, Early T-cell activation antigen p60, GP32/28, Leukocyte surface antigen Leu-23, MLR-3, CD69, CD69, CLEC2C |
| Target/Specificity | This CD69 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human CD69. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD69 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD69 |
|---|---|
| Synonyms | CLEC2C |
| Function | Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Acts also via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells (PubMed:26296369). Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T- lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT (PubMed:35930205). Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P. aeruginosa infection. Mechanistically, specifically recognizes P. aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (PubMed:34841721). In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:37039481). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed on the surface of activated T-cells, B- cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. Alternative splicing results in multiple transcript variants.
References
Davila, S., et al. Genes Immun. (2010) In press :
Kolenko, P., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 12), 1258-1260 (2009) :
Hu, M., et al. J. Mol. Recognit. 22(6):516-520(2009)
Radstake, T.R., et al. PLoS ONE 4 (6), E5981 (2009) :
Natarajan, K., et al. Biochemistry 39(48):14779-14786(2000)
Vance, B.A., et al. Arch. Biochem. Biophys. 368(2):214-220(1999)
Lopez-Cabrera, M., et al. J. Biol. Chem. 270(37):21545-21551(1995)
Bezouska, K., et al. Biochem. Biophys. Res. Commun. 208(1):68-74(1995)
Santis, A.G., et al. Eur. J. Immunol. 24(7):1692-1697(1994)
Lopez-Cabrera, M., et al. J. Exp. Med. 178(2):537-547(1993)
Ziegler, S.F., et al. Eur. J. Immunol. 23(7):1643-1648(1993)
Cambiaggi, C., et al. Immunogenetics 36(2):117-120(1992)
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