Anti-PTGIS Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q16647 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 57104 Da |
Gene ID | 5740 |
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Other Names | CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase |
Target/Specificity | Recognizes endogenous levels of PTGIS protein. |
Dilution | WB~~1/500 - 1/1000 |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | PTGIS |
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Synonyms | CYP8, CYP8A1 |
Function | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)- HPETE) (PubMed:17459323). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29626}; Single-pass membrane protein |
Tissue Location | Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rabbit polyclonal antibody to PTGIS
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