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Anti-PSA Mouse mAb
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC |
|---|---|
| Primary Accession | P07288 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Immunogen | Purified recombinant fragment of KLK3 (aa26-251) expressed in E. Coli. |
| Purification | Acites |
| Calculated MW | 28741 Da |
| Antigen Region | aa26-251 |
| Gene ID | 354 |
|---|---|
| Other Names | APS; PSA; hK3; KLK2A1; KLK3 |
| Dilution | IHC~~1:1000 |
| Format | Ascitic fluid containing 0.09% (W/V) sodium azide. |
| Storage | Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | KLK3 |
|---|---|
| Synonyms | APS |
| Function | Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kallikrein-related peptidase 3.Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
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