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Anti-Cytokeratin 18 Mouse mAb
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P05783 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Immunogen | Purified recombinant fragment of human Cytokeratin 18 (aa391-483) expressed in E. Coli. |
| Purification | Acites |
| Calculated MW | 48kDa |
| Antigen Region | aa391-483 |
| Gene ID | 3875 |
|---|---|
| Other Names | CK18; CYK18; KRT18 |
| Dilution | IHC~~1:400 |
| Format | Ascitic fluid containing 0.09% (W/V) sodium azide. |
| Storage | Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | KRT18 |
|---|---|
| Synonyms | CYK18 |
| Function | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Cellular Location | Nucleus matrix {ECO:0000250|UniProtKB:Q5BJY9}. Cytoplasm, perinuclear region. Nucleus, nucleolus. Cytoplasm {ECO:0000250|UniProtKB:Q5BJY9} |
| Tissue Location | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytokeratin 18, also known as CK18, CYK18, KRT18. Entrez Protein NP_000215. It encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
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