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IDUA Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P35475 |
| Other Accession | NP_000194.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72670 Da |
| Antigen Region | 236-264 aa |
| Gene ID | 3425 |
|---|---|
| Other Names | Alpha-L-iduronidase, IDUA |
| Target/Specificity | This IDUA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-264 amino acids from the Central region of human IDUA. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IDUA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IDUA |
|---|---|
| Cellular Location | Lysosome. |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
IDUA encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans.
References
Amr, K., et al. Genet Test Mol Biomarkers 13(6):761-764(2009)
Vazna, A., et al. Am. J. Med. Genet. A 149A (5), 965-974 (2009)
Sugawara, K., et al. J. Hum. Genet. 53(5):467-474(2008)
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