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Anti-PKM2 Antibody
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | P14618 |
| Other Accession | NM_002654 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Immunogen | Purified full-length of recombinant human PKM2 protein expressed in E.coli. |
| Purification | Affinity purified |
| Calculated MW | 60 KDa |
| Gene ID | 5315 |
|---|---|
| Other Names | CTHBP;Cytosolic thyroid hormone binding protein;Cytosolic thyroid hormone-binding protein;KPYM_HUMAN;MGC3932;OIP 3;OIP-3;OIP3;OPA interacting protein 3;Opa-interacting protein 3;p58;PK muscle type;PK, muscle type;PK2;PK3;PKM;PKM2;pykm;Pyruvate kinase 2/3;Pyruvate kinase 3;Pyruvate kinase isozymes M1/M2;Pyruvate kinase muscle;Pyruvate kinase muscle isozyme;pyruvate kinase PKM;Pyruvate kinase, muscle 2;TCB;THBP1;Thyroid hormone binding protein 1;Thyroid hormone binding protein cytosolic;Thyroid hormone-binding protein 1;Tumor M2 PK;Tumor M2-PK. |
| Dilution | WB~~1:1000 ICC~~1:400 |
| Format | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | PKM |
|---|---|
| Synonyms | OIP3 {ECO:0000303|PubMed:9466265}, PK2, |
| Function | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). |
| Cellular Location | [Isoform M2]: Cytoplasm. Nucleus Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylation by EP300 (PubMed:24120661). Deacetylation by SIRT6 promotes its nuclear export in a process dependent of XPO4, thereby suppressing its ability to activate transcription and promote tumorigenesis (PubMed:26787900). |
| Tissue Location | [Isoform M2]: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ra
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$ 360.00
Cat# AP53402
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