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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > Anti-Hexokinase II Antibody
Anti-Hexokinase II Antibody
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P52789 |
| Other Accession | NM_000189 |
| Reactivity | Mouse, Rat, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Immunogen | Recombinant human Hexokinase II protein. |
| Purification | Affinity purified |
| Calculated MW | 102 KDa |
| Gene ID | 3099 |
|---|---|
| Other Names | DKFZp686M1669;Hexokinase 2;Hexokinase 2 muscle;Hexokinase type II;Hexokinase-2;HK 2;HK II;HK2;HKII;HxK 2;HxK2;HXK2_HUMAN;Muscle form hexokinase. |
| Dilution | WB~~1:500 |
| Format | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | HK2 (HGNC:4923) |
|---|---|
| Function | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). |
| Cellular Location | Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880) The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175). |
| Tissue Location | Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle |
Research Areas
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$ 360.00
Cat# AP53398
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