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Anti-Wnt3a Antibody
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P56704 |
| Other Accession | NM_033131 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Immunogen | Purified recombinant Wnt3a protein fragments expressed in E.coli. |
| Purification | Affinity purified |
| Calculated MW | 42 KDa |
| Gene ID | 89780 |
|---|---|
| Other Names | MGC119418 ;MGC119419 ;MGC119420 ;Protein Wnt 3a Precursor ;Protein Wnt-3a ;Wingless type MMTV integration site family member 3A ;Wnt 3a ;wnt3a ;WNT3A protein ;WNT3A_HUMAN. |
| Dilution | WB~~1:1000 |
| Format | PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | WNT3A |
|---|---|
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P27467}. Secreted |
| Tissue Location | Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
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