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Eg5 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, IP |
|---|---|
| Primary Accession | P52732 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 130 KDa |
| Gene ID | 3832 |
|---|---|
| Other Names | EG5;HKSP;KIF11;KIF11_HUMAN;kinesin family member 11;Kinesin like protein 1;Kinesin like spindle protein HKSP;Kinesin-like protein 1;Kinesin-like protein KIF11;Kinesin-like spindle protein HKSP;Kinesin-related motor protein Eg5;KNSL1;MCLMR;Thyroid receptor interacting protein 5;Thyroid receptor-interacting protein 5;TR-interacting protein 5; TRIP-5;TRIP5. |
| Dilution | IP~~1:500 WB~~1:1000 ICC~~1:200 |
| Format | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | KIF11 |
|---|---|
| Synonyms | EG5, KNSL1, TRIP5 |
| Function | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, spindle pole |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
References
Blangy A.,et al.Cell 83:1159-1169(1995).
Whitehead C.M.,et al.J. Cell Sci. 111:2551-2561(1998).
Deloukas P.,et al.Nature 429:375-381(2004).
Lee J.W.,et al.Mol. Endocrinol. 9:243-254(1995).
Beausoleil S.A.,et al.Nat. Biotechnol. 24:1285-1292(2006).
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