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cIAP2 Antibody
Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q13489 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 72 KDa |
| Gene ID | 330 |
|---|---|
| Other Names | AIP 1;AIP1;API 2;API2;API2;Apoptosis inhibitor 2;Baculoviral IAP repeat containing 3;Baculoviral IAP repeat containing protein 3;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;BIRC3;BIRC3_HUMAN;C IAP2;C-IAP2;CIAP 2;CIAP 2;CIAP2;HAIP 1;HAIP1;HAIP1; HIAP 1;HIAP-1;HIAP1;IAP homolog C;IAP-1;Inhibitor of apoptosis protein 1;Inhibitor of apoptosis protein 1;MALT 2;MALT2;Mammalian IAP homolog C;MIHC;MIHC;RING finger protein 49;RNF49;TNFR2 TRAF signaling complex protein 1;TNFR2 TRAF signalling complex protein;TNFR2-TRAF-signaling complex protein 1. |
| Dilution | WB~~1:1000 |
| Format | ascites |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | BIRC3 |
|---|---|
| Synonyms | API2, MIHC, RNF49 |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes |
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Background
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
References
Rothe M.,et al.Cell 83:1243-1252(1995).
Liston P.,et al.Nature 379:349-353(1996).
Uren A.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:4974-4978(1996).
Horrevoets A.J.G.,et al.Blood 93:3418-3431(1999).
Baens M.,et al.Genes Chromosomes Cancer 29:281-291(2000).
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