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c-JUN Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P05412 |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 43/48 KDa |
| Gene ID | 3725 |
|---|---|
| Other Names | Activator Protein 1;AP 1;AP1;cJun;Enhancer Binding Protein AP1;Jun Activation Domain Binding Protein;JUN;Jun oncogene;JUN protein;Jun proto oncogene;JUN_HUMAN;JUNC;Oncogene JUN;p39;Proto oncogene c jun;Proto oncogene cJun;Proto-oncogene c-jun;Transcription Factor AP 1;Transcription factor AP-1;Transcription Factor AP1;V jun avian sarcoma virus 17 oncogene homolog;V jun sarcoma virus 17 oncogene homolog (avian);V jun sarcoma virus 17 oncogene homolog;V-jun avian sarcoma virus 17 oncogene homolog;vJun Avian Sarcoma Virus 17 Oncogene Homolog. |
| Dilution | WB~~1:1000 |
| Format | Purified mouse monoclonal in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | JUN |
|---|---|
| Function | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in the developing and adult prostate and prostate cancer cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
References
Hattori K.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:9148-9152(1988).
Bohmann D.,et al.Science 238:1386-1392(1987).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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