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SAFB1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q15424 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 130 KDa |
| Gene ID | 6294 |
|---|---|
| Other Names | DKFZp779C1727;glutathione S transferase fusion protein;HAP;HET;HSP27 ERE TATA binding protein;HSP27 ERE-TATA-binding protein;HSP27 estrogen response element-TATA box-binding protein;SAF B;SAF-B1;SAFB 1;SAFB;SAFB1;SAFB1_HUMAN;scaffold attachment factor B1. |
| Dilution | WB~~1:1000 ICC~~1:200 |
| Format | Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.09% (W/V) sodium azide, 50%,glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SAFB |
|---|---|
| Synonyms | HAP, HET, SAFB1 |
| Function | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). |
| Cellular Location | Nucleus |
| Tissue Location | Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation.
References
Oesterreich S.,et al.J. Cell. Biochem. 67:275-286(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (JUL-2009) to UniProtKB.
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