PP2A alpha and beta Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IP |
---|---|
Primary Accession | P62714 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a |
Calculated MW | 36 KDa |
Gene ID | 5516 |
---|---|
Other Names | PP2A beta;PP2A-beta;PP2AB_HUMAN;PP2Abeta;PP2CB;Ppp2cb;Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform;Protein phosphatase 2 catalytic subunit beta isozyme;Protein phosphatase 2, catalytic subunit, beta isoform;Protein phosphatase 2A catalytic subunit beta isoform;Protein phosphatase type 2A catalytic subunit;Serine/threonine protein phosphatase 2A catalytic subunit beta;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform. |
Dilution | IP~~1:500 WB~~1:2000 |
Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.09% (W/V) sodium azide,50% glycerol. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | PPP2CB (HGNC:9300) |
---|---|
Function | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). |
Cellular Location | Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
References
Hemmings B.A.,et al.Nucleic Acids Res. 16:11366-11366(1988).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Arino J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4252-4256(1988).
Khew-Goodall Y.,et al.Biochemistry 30:89-97(1991).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.