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COX IV Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC, IP |
|---|---|
| Primary Accession | P13073 |
| Reactivity | Human, Mouse, Neisseria Gonorrhoeae |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 17 KDa |
| Gene ID | 1327 |
|---|---|
| Other Names | AL024441;COX 4;COX IV 1;COX IV;COX IV-1;Cox4;COX41_HUMAN;Cox4a;COX4B;COX4I1;COX4I2; COX4L2;COXIV;Cytochrome c oxidase polypeptide IV;Cytochrome c oxidase subunit 4 isoform 1 mitochondrial;Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;Cytochrome C Oxidase subunit IV;Cytochrome c oxidase subunit IV isoform 1;Cytochrome c oxidase subunit IV isoform 2 (lung);Cytochrome c oxydase subunit;dJ857M17.2;MGC105470;MGC72016. |
| Dilution | IP~~1:500 WB~~1:1000 FC~~1:100 ICC~~1:150 |
| Format | Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.09% (W/V) sodium azide,0.1mg/mlBSA and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | COX4I1 (HGNC:2265) |
|---|---|
| Function | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
| Tissue Location | Ubiquitous. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
References
Zeviani M.,et al.Gene 55:205-217(1987).
Lomax M.I.,et al.Gene 86:209-216(1990).
Park S.J.,et al.Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
Bachman N.J.,et al.Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
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$ 385.00
Cat# AP52659
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