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KLF4 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O43474 |
| Reactivity | Transfected |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Calculated MW | 55/65 KDa |
| Gene ID | 9314 |
|---|---|
| Other Names | Endothelial Kruppel like zinc finger protein;Epithelial zinc finger protein EZF;EZF;GKLF;Gut-enriched krueppel-like factor;KLF;KLF4;KLF4_HUMAN;Krueppel-like factor 4;Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor);Kruppel like factor 4 (gut). |
| Dilution | WB~~1:1000 |
| Format | ascites |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | KLF4 (HGNC:6348) |
|---|---|
| Synonyms | EZF, GKLF |
| Function | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q60793}. Cytoplasm {ECO:0000250|UniProtKB:Q60793} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
References
Yet S.-F.,et al.J. Biol. Chem. 273:1026-1031(1998).
Foster K.W.,et al.Cell Growth Differ. 10:423-434(1999).
Camacho-Vanegas O.,et al.FASEB J. 27:432-436(2013).
Garrett-Sinha L.A.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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