MGST2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q99735 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 17 KDa |
Antigen Region | 1 - 60 aa |
Gene ID | 4258 |
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Other Names | Microsomal glutathione S-transferase 2, Microsomal GST-2, Microsomal GST-II, MGST2, GST2 |
Target/Specificity | KLH conjugated synthetic peptide derived from human MGST2 |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | MGST2 |
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Synonyms | GST2 |
Function | Catalyzes several different glutathione-dependent reactions (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:23409838, PubMed:9278457). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi- pass membrane protein |
Tissue Location | Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow (PubMed:8703034) Abundantly expressed in human umbilical vein endothelial cells (at protein level) (PubMed:11322876). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione.
References
Jakobsson P.-J.,et al.J. Biol. Chem. 271:22203-22210(1996).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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