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ETAA1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NY74 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 103 KDa |
| Gene ID | 54465 |
|---|---|
| Other Names | Ewing's tumor-associated antigen 1, Ewing's tumor-associated antigen 16, ETAA1, ETAA16 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | ETAA1 (HGNC:24648) |
|---|---|
| Function | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). |
| Cellular Location | Nucleus Note=Localizes at sites of DNA damage following replication stress (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with RPA1 and RPA2 subunits of the RPA complex (PubMed:27601467, PubMed:27723720) |
| Tissue Location | Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Borowski A.,et al.Cancer Immunol. Immunother. 55:363-374(2006).
Hillier L.W.,et al.Nature 434:724-731(2005).
Matsuoka S.,et al.Science 316:1160-1166(2007).
Sjoeblom T.,et al.Science 314:268-274(2006).
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