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Tyrosinase Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P14679 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60.4 KDa |
| Antigen Region | 461 - 520 aa |
| Gene ID | 7299 |
|---|---|
| Other Names | Tyrosinase, LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB, TYR |
| Target/Specificity | KLH conjugated synthetic peptide derived from human Tyrosinase |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TYR (HGNC:12442) |
|---|---|
| Function | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4- dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA- quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582). |
| Cellular Location | Melanosome membrane; Single-pass type I membrane protein. Melanosome {ECO:0000250|UniProtKB:P11344}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38 {ECO:0000250|UniProtKB:P11344} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
References
Giebel L.B.,et al.Genomics 9:435-445(1991).
Kwon B.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:7473-7477(1987).
Kwon B.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:6352-6352(1988).
Bouchard B.,et al.J. Exp. Med. 169:2029-2042(1989).
Chintamaneni C.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:5272-5276(1991).
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