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Tensin 1 (pY1326) Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HBL0 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 200 KDa |
| Gene ID | 7145 |
|---|---|
| Other Names | Tensin-1, TNS1, TNS |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TNS1 |
|---|---|
| Synonyms | TNS |
| Function | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). |
| Cellular Location | Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localizes to both focal adhesions and fibrillar adhesions (PubMed:20069572). Localized at the cell periphery preferentially to fibrillar adhesions rather than to focal adhesions. Translocates from the cell edge to the cell center in an ITGB1BP1-dependent manner (PubMed:21768292) |
| Tissue Location | In the lung, detected in the alveolar septa (at protein level) (PubMed:28005397). Ubiquitous (PubMed:11023826) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
References
Chen H.,et al.Biochem. J. 351:403-411(2000).
Hillier L.W.,et al.Nature 434:724-731(2005).
Bienvenut W.V.,et al.Submitted (OCT-2009) to UniProtKB.
Qian X.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:9012-9017(2007).
Cantin G.T.,et al.J. Proteome Res. 7:1346-1351(2008).
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