CD120b Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IP, ICC, IHC-P, E |
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Primary Accession | P20333 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 48 KDa |
Gene ID | 7133 |
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Other Names | Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, CD120b, Etanercept, Tumor necrosis factor receptor superfamily member 1b, membrane form, Tumor necrosis factor-binding protein 2, TBP-2, TBPII, TNFRSF1B, TNFBR, TNFR2 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | TNFRSF1B |
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Synonyms | TNFBR, TNFR2 |
Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Tumor necrosis factor-binding protein 2]: Secreted |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
References
Kohno T.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990).
Smith C.A.,et al.Science 248:1019-1023(1990).
Beltinger C.P.,et al.Genomics 35:94-100(1996).
Lainez B.,et al.Int. Immunol. 16:169-177(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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