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Serpin B5 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P36952 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42 KDa |
| Antigen Region | 71 - 130 aa |
| Gene ID | 5268 |
|---|---|
| Other Names | Serpin B5, Maspin, Peptidase inhibitor 5, PI-5, SERPINB5, PI5 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human Serpin B5 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SERPINB5 |
|---|---|
| Synonyms | PI5 |
| Function | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| Cellular Location | Secreted, extracellular space. |
| Tissue Location | Normal mammary epithelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
References
Zou Z.,et al.Science 263:526-529(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Pemberton P.A.,et al.J. Biol. Chem. 270:15832-15837(1995).
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