PFKL Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB |
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Primary Accession | P17858 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 80 KDa |
Antigen Region | 701 - 760 aa |
Gene ID | 5211 |
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Other Names | ATP-dependent 6-phosphofructokinase, liver type {ECO:0000255|HAMAP-Rule:MF_03184}, ATP-PFK {ECO:0000255|HAMAP-Rule:MF_03184}, PFK-L, 27111 {ECO:0000255|HAMAP-Rule:MF_03184}, 6-phosphofructokinase type B, Phosphofructo-1-kinase isozyme B, PFK-B, Phosphohexokinase {ECO:0000255|HAMAP-Rule:MF_03184}, PFKL |
Target/Specificity | KLH conjugated synthetic peptide derived from human PFKL |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | PFKL (HGNC:8876) |
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Function | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). |
Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}. |

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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
References
Levanon D.,et al.DNA 8:733-743(1989).
Elson A.,et al.Genomics 7:47-56(1990).
Hattori M.,et al.Nature 405:311-319(2000).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Bienvenut W.V.,et al.Submitted (JUL-2009) to UniProtKB.

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