Cathepsin D LC Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | P07339 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 11 KDa |
Antigen Region | 21 - 80 aa |
Gene ID | 1509 |
---|---|
Other Names | Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD |
Target/Specificity | KLH conjugated synthetic peptide derived from human Cathepsin D LC |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | CTSD |
---|---|
Synonyms | CPSD |
Function | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. |
Cellular Location | Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380) |
Tissue Location | Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
References
Faust P.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985).
Westley B.R.,et al.Nucleic Acids Res. 15:3773-3786(1987).
Redecker B.,et al.DNA Cell Biol. 10:423-431(1991).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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