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Adenylate Cyclase 5/6 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O95622 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 139 KDa |
| Antigen Region | 1031 - 1090 aa |
| Gene ID | 111 |
|---|---|
| Other Names | Adenylate cyclase type 5, ATP pyrophosphate-lyase 5, Adenylate cyclase type V, Adenylyl cyclase 5, ADCY5 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human Adenylate Cyclase 5/6 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | ADCY5 |
|---|---|
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:24700542, PubMed:26206488). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250|UniProtKB:P84309} |
| Tissue Location | Detected in pancreas islets (at protein level). Expressed in the brain, with high expression in the corpus striatum (PubMed:26085604). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Ludwig M.G.,et al.J. Recept. Signal Transduct. 22:79-110(2002).
Raimundo S.,et al.Clin. Chim. Acta 285:155-161(1999).
Ding Q.,et al.Mol. Pharmacol. 66:921-928(2004).
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