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CABC1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8NI60 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 72 KDa |
| Antigen Region | 281 - 340 aa |
| Gene ID | 56997 |
|---|---|
| Other Names | Chaperone activity of bc1 complex-like, mitochondrial, Chaperone-ABC1-like, 2711-, aarF domain-containing protein kinase 3, ADCK3, CABC1 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human CABC1 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | COQ8A {ECO:0000303|PubMed:27499294, ECO:0000312|HGNC:HGNC:16812} |
|---|---|
| Function | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:21296186, PubMed:25498144, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144). |
| Cellular Location | Mitochondrion. Membrane; Single-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:25216398} |
| Tissue Location | Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Putative protein kinase involved in the biosynthesis of coenzyme Q since it is able to rescue partially coenzyme Q6 biosynthesis of yeast COQ8 mutants. May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
References
Iiizumi M.,et al.Cancer Res. 62:1246-1250(2002).
Ievolella C.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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