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GATA6-Y271 Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GATA6-Y271 Antibody AP5065D
    Western blot analysis of Phospho-GATA6-pY271 (Cat. #AP5065d) in WiDr cell line lysates (35ug/lane).GATA6 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q92908
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 60033 Da
Antigen Region 254-279 aa
Additional Information
Gene ID 2627
Other Names Transcription factor GATA-6, GATA-binding factor 6, GATA6
Target/Specificity This GATA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-279 amino acids from human GATA6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGATA6-Y271 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GATA6
Function Transcriptional activator (PubMed:19666519, PubMed:22750565, PubMed:22824924, PubMed:27756709). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti- inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341).
Cellular Location Nucleus
Tissue Location Expressed in heart, gut and gut-derived tissues. Expressed in skin upper pilosebaceous unit. Expression is decreased or lost in acne lesions (PubMed:33082341).
Research Areas
Citations (0)
citation

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Background

GATA6 is thought to be important for regulating terminal differentiation and/or proliferation.

References

Capo-chichi, C.D., et al. Mol. Cell. Biol. 29(17):4766-4777(2009) Nakamura, Y., et al. Endocrinology 150(9):4145-4153(2009) Tan, N.Y., et al. Circ. Res. 105(5):422-430(2009)

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$ 365.00
$ 140.00
Cat# AP5065D
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