MIIP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q5JXC2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42824 Da |
Antigen Region | 275-303 aa |
Gene ID | 60672 |
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Other Names | Migration and invasion-inhibitory protein, IGFBP2-binding protein, Invasion-inhibitory protein 45, IIp45, MIIP, IIP45 |
Target/Specificity | This MIIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the C-terminal region of human MIIP. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MIIP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MIIP |
---|---|
Synonyms | IIP45 |
Function | Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. |
Tissue Location | Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MIIP inhibits glioma cells invasion and down-regulates adhesion-and motility-associated genes such as NFKB2 and ICAM1. MIIP exhibits opposing effects to IGFBP2 on cell invasion.
References
Wu, Y., et al. J. Biol. Chem. 285(6):3554-3560(2010) Song, F., et al. Cancer Res. 70(3):1024-1032(2010) Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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