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SLC28A2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | O43868 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 72 KDa |
| Antigen Region | 385-414 aa |
| Gene ID | 9153 |
|---|---|
| Other Names | Sodium/nucleoside cotransporter 2, Concentrative nucleoside transporter 2, CNT 2, hCNT2, Na(+)/nucleoside cotransporter 2, Sodium-coupled nucleoside transporter 2, Sodium/purine nucleoside co-transporter, SPNT, Solute carrier family 28 member 2, SLC28A2, CNT2 |
| Dilution | WB~~ 1:1000 IHC~~1:50-1:100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | SLC28A2 |
|---|---|
| Synonyms | CNT2 |
| Function | Sodium-dependent and purine-selective transporter (PubMed:10087507, PubMed:9435697). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:10087507, PubMed:21795683, PubMed:9435697). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues (PubMed:9435697). May contribute to regulate the transport of organic compounds in testes across the blood-testis- barrier (Probable). |
| Cellular Location | Membrane; Multi-pass membrane protein. Apicolateral cell membrane; Multi-pass membrane protein. Note=Localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells in testis |
| Tissue Location | Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain (PubMed:9435697). Weak expression in lung (PubMed:9435697). In testis, primarily localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells, and weakly expressed in Leydig cells, peritubular myoid cells and germ cells (PubMed:35307651) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
References
Wang J.,et al.Am. J. Physiol. 273:F1058-F1065(1997).
Ritzel M.W.L.,et al.Mol. Membr. Biol. 15:203-211(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Loewen S.K.,et al.J. Biol. Chem. 274:24475-24484(1999).
Owen R.P.,et al.Pharmacogenet. Genomics 15:83-90(2005).
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