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GLRX5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q86SX6 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16628 Da |
| Antigen Region | 129-157 aa |
| Gene ID | 51218 |
|---|---|
| Other Names | Glutaredoxin-related protein 5, mitochondrial, Monothiol glutaredoxin-5, GLRX5, C14orf87 |
| Target/Specificity | This GLRX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-157 amino acids from the C-terminal region of human GLRX5. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GLRX5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLRX5 |
|---|---|
| Synonyms | C14orf87 |
| Function | Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron- sulfur protein ACO1 (PubMed:20364084). |
| Cellular Location | Mitochondrion matrix |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GLRX5 is monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. GLRX5 required for normal iron homeostasis. GLRX5 is required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
References
Bergmann, A.K., et al. Pediatr Blood Cancer 54(2):273-278(2010)
Camaschella, C., et al. Blood 110(4):1353-1358(2007)
Wingert, R.A., et al. Nature 436(7053):1035-1039(2005)
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