SHC3 HUMAN
Affinity-Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
---|---|
Primary Accession | Q92529 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 64.06 KDa |
Antigen Region | 305-330 aa |
Gene ID | 53358 |
---|---|
Other Names | SHC-transforming protein 3, Neuronal Shc, N-Shc, Protein Rai, SHC-transforming protein C, Src homology 2 domain-containing-transforming protein C3, SH2 domain protein C3, SHC3, NSHC, SHCC |
Dilution | WB~~ 1:1000 IHC~~1:50-1:100 |
Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
Storage Conditions | -20℃ |
Name | SHC3 |
---|---|
Synonyms | NSHC, SHCC |
Function | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. |
Tissue Location | Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
References
Nakamura T.,et al.Oncogene 13:1111-1121(1996).
Pelicci G.,et al.Oncogene 13:633-641(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Liu H.Y.,et al.J. Biol. Chem. 277:26046-26056(2002).
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