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RAB27B Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RAB27B  Antibody (C-term) AP4986b
    Western blot analysis of RAB27B Antibody (C-term) (Cat. #AP4986b) in NCI-H460 cell line lysates (35ug/lane). RAB27B (arrow) was detected using the purified Pab.
    detail
  • FC - RAB27B  Antibody (C-term) AP4986b
    RAB27B Antibody (C-term) (Cat. #AP4986b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession O00194
Other Accession NP_004154
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 24608 Da
Antigen Region 186-215 aa
Additional Information
Gene ID 5874
Other Names Ras-related protein Rab-27B, C25KG, RAB27B
Target/Specificity This RAB27B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the C-terminal region of human RAB27B.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB27B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB27B
Function Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).
Cellular Location Membrane; Lipid-anchor. Late endosome
Tissue Location Expressed primarily in testis.
Research Areas
Citations (0)
citation

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Background

RAB27B may be involved in targeting uroplakins to urothelial apical membranes.

References

Hayasaka, S., et al. Asian J. Androl. 10(4):561-568(2008)
Shirakawa, R., et al. J. Biol. Chem. 279(11):10730-10737(2004)
Tiwari, S., et al. Blood 102(12):3970-3979(2003)

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$ 365.00
$ 140.00
Cat# AP4986b
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