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TXNDC12 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TXNDC12 Antibody (C-term) AP4871b
    Western blot analysis of TXNDC12 Antibody (C-term) (Cat. #AP4871b) in Y79 cell line lysates (35ug/lane). TXNDC12 (arrow) was detected using the purified Pab.
    detail
  • WB - TXNDC12 Antibody (C-term) AP4871b
    Western blot analysis of TXNDC12 Antibody (C-term) (Cat. #AP4871b) in mouse stomach tissue lysates (35ug/lane). TXNDC12 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - TXNDC12 Antibody (C-term) AP4871b
    TXNDC12 Antibody (C-term) (Cat. #AP4871b) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TXNDC12 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession O95881
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 19206 Da
Antigen Region 144-172 aa
Additional Information
Gene ID 51060
Other Names Thioredoxin domain-containing protein 12, Endoplasmic reticulum resident protein 18, ER protein 18, ERp18, Endoplasmic reticulum resident protein 19, ER protein 19, ERp19, Thioredoxin-like protein p19, hTLP19, TXNDC12, TLP19
Target/Specificity This TXNDC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-172 amino acids from the C-terminal region of human TXNDC12.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTXNDC12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXNDC12 (HGNC:24626)
Function Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol- disulfide oxidase activity.
Cellular Location Endoplasmic reticulum lumen {ECO:0000255|PROSITE- ProRule:PRU10138, ECO:0000269|PubMed:12761212}
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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Background

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors

References

Jessop, C.E., et al. J. Cell. Sci. 122 (PT 23), 4287-4295 (2009)
Rowe, M.L., et al. Biochemistry 48(21):4596-4606(2009)
Jeong, W., et al. J. Biol. Chem. 283(37):25557-25566(2008)

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$ 365.00
$ 140.00
Cat# AP4871b
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