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Phospho-Gab1(Y659) Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • DB - Phospho-Gab1(Y659) Antibody AP3302b
    Dot blot analysis of Phospho-Gab1-Y659 polyclonal antibody (Cat. AP3302b) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration were 0.5ug per ml.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
DB, E
Primary Accession Q13480
Other Accession Q9QYY0, A6QLU3
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 76616 Da
Additional Information
Gene ID 2549
Other Names GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1
Target/Specificity This Gab1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y659 of human Gab1.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Gab1(Y659) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAB1
Function Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).
Research Areas
Citations (0)
citation

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Background

Gab1 is a member of the IRS1-like multisubstrate docking protein family. This protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.

References

Podar, K., et al., J. Biol. Chem. 279(20):21658-21665 (2004).
Ren, Y., et al., J. Biol. Chem. 279(9):8497-8505 (2004).
Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004).
Nakaoka, Y., et al., Circ. Res. 93(3):221-229 (2003).
Holgado-Madruga, M., et al., Mol. Cell. Biol. 23(13):4471-4484 (2003).

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$ 182.50
$ 70.00
Cat# AP3302b
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