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Phospho-JUN(T243) Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| DB, E |
|---|---|
| Primary Accession | P05412 |
| Other Accession | P17325, P56432, P05627, P18870, O77627 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Mouse, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35676 Da |
| Gene ID | 3725 |
|---|---|
| Other Names | Transcription factor AP-1, Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN |
| Target/Specificity | This JUN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T243 of human JUN. |
| Dilution | DB~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Phospho-JUN(T243) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JUN |
|---|---|
| Function | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in the developing and adult prostate and prostate cancer cells. |
- Primary Antibodies
- Cancer
- Immunology
- Signal Transduction
- Antibody Collections
- Phospho Antibodies
- Anti-Wnt-Pathway (plus Lgr5) Antibodies
- Toll receptor signaling
- Toll-Like Receptor
- Toll-Like receptor signaling
- B cell receptor signaling
- T cell activation
- T cell receptor signaling
- Inflammation mediated by chemokine and cytokine signaling
- Apoptosis signaling
- SARS-Human interaction partners
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene for the cJun protein is the putative transforming gene of avian sarcoma virus 17. The protein is highly similar to the viral protein, and interacts directly with specific target DNA sequences to regulate gene expression. The gene for this protein is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
References
Fang, D., et al., Proc. Natl. Acad. Sci. U.S.A. 101(41):14782-14787 (2004).
Wang, Y., et al., Biochem. Biophys. Res. Commun. 323(1):9-16 (2004).
Wehkamp, J., et al., Infect. Immun. 72(10):5750-5758 (2004).
Gensch, E., et al., J. Biol. Chem. 279(37):39085-39093 (2004).
Fujioka, S., et al., Mol. Cell. Biol. 24(17):7806-7819 (2004).
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