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CD138 Antibody (C-term K281)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CD138 Antibody (C-term K281) AP2948b
    Western blot analysis of CD138 Antibody (C-term K281) (Cat. #AP2948b) in HepG2 cell line lysates (35ug/lane). CD138 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P18827
Other Accession P26260, P18828, P47951, Q08DZ5
Reactivity Human
Predicted Bovine, Hamster, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 32462 Da
Antigen Region 266-295 aa
Additional Information
Gene ID 6382
Other Names Syndecan-1, SYND1, CD138, SDC1, SDC
Target/Specificity This CD138 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the C-terminal region of human CD138.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD138 Antibody (C-term K281) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SDC1 (HGNC:10658)
Synonyms SDC
Function Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein. Secreted Secreted, extracellular exosome Note=Shedding of the ectodomain produces a soluble form
Tissue Location Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313).
Research Areas
Citations (0)
citation

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Background

CD138 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins.

References

Rikova,K., et.al., Cell 131 (6), 1190-1203 (2007)
Endo,K., et.al., J. Biol. Chem. 278 (42), 40764-40770 (2003)

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$ 365.00
$ 140.00
Cat# AP2948b
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