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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > TUFM Antibody (N-term)
TUFM Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P49411 |
| Other Accession | P85834, Q8BFR5, P49410 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49875 Da |
| Antigen Region | 75-104 aa |
| Gene ID | 7284 |
|---|---|
| Other Names | Elongation factor Tu, mitochondrial, EF-Tu, P43, TUFM |
| Target/Specificity | This TUFM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the N-terminal region of human TUFM. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TUFM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TUFM |
|---|---|
| Function | Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. |
| Cellular Location | Mitochondrion. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
TUFM is a protein which participates in protein translation in mitochondria. This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
References
Valente,L., et.al., Biochim. Biophys. Acta 1792 (8), 791-795 (2009)
Bogenhagen,D.F., et.al., J. Biol. Chem. 283 (6), 3665-3675 (2008)
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$ 182.50
$ 70.00
Cat# AP2918a
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