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CDA Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - CDA Antibody (Center) AP2868c
    Western blot analysis of lysates from Hela cell line, human liver and mouse kidney tissue lysate(from left to right), using CDA Antibody (Center)(Cat. #AP2868c). AP2868c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P32320
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 16185 Da
Antigen Region 51-83 aa
Additional Information
Gene ID 978
Other Names Cytidine deaminase, Cytidine aminohydrolase, CDA, CDD
Target/Specificity This CDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from the Central region of human CDA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDA (HGNC:1712)
Synonyms CDD
Function This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Tissue Location Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines
Research Areas
Citations (0)
citation

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Background

CDA forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. This protein is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in the CDA gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

References

Laliberte J., Momparler R.L.Cancer Res. 54:5401-5407(1994)
Demontis S., Terao M.Biochim. Biophys. Acta 1443:323-333(1998)
Kuhn K., Bertling W.M., Emmrich F.Biochem. Biophys. Res. Commun. 190:1-7(1993)

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$ 365.00
$ 140.00
Cat# AP2868c
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