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CDA Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P32320 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16185 Da |
| Antigen Region | 51-83 aa |
| Gene ID | 978 |
|---|---|
| Other Names | Cytidine deaminase, Cytidine aminohydrolase, CDA, CDD |
| Target/Specificity | This CDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from the Central region of human CDA. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDA (HGNC:1712) |
|---|---|
| Synonyms | CDD |
| Function | This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. |
| Tissue Location | Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CDA forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. This protein is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in the CDA gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
References
Laliberte J., Momparler R.L.Cancer Res. 54:5401-5407(1994)
Demontis S., Terao M.Biochim. Biophys. Acta 1443:323-333(1998)
Kuhn K., Bertling W.M., Emmrich F.Biochem. Biophys. Res. Commun. 190:1-7(1993)
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