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HNF4A Antibody (S142)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HNF4A Antibody (S142) AP2778a
    Western blot analysis of anti-HNF4A Antibody (S142) (Cat.#AP2778a) in NCI-H460 cell line lysates (35ug/lane). HNF4A (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P41235
Other Accession Q91766, P22449, P49698, NP_849180
Reactivity Human
Predicted Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52785 Da
Antigen Region 118-146 aa
Additional Information
Gene ID 3172
Other Names Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14
Target/Specificity This HNF4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from human HNF4A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHNF4A Antibody (S142) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNF4A
Synonyms HNF4, NR2A1, TCF14
Function Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).
Cellular Location Nucleus.
Research Areas
Citations (0)
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Background

HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This protein may play a role in development of the liver, kidney, and intestines. Mutations in this protein have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I.

References

Sugai,M., Pathol. Int. 58 (11), 681-686 (2008)
Lee,S.S., Hepatology 48 (2), 635-645 (2008)
Guo,H., Biochem. J. 394 (PT 2), 379-387 (2006)
Hong,Y.H., J. Biol. Chem. 278 (30), 27495-27501 (2003)

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$ 365.00
$ 140.00
Cat# AP2778a
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