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UGP2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q16851 |
| Other Accession | P79303, Q91ZJ5, O35156, Q07130 |
| Reactivity | Human |
| Predicted | Bovine, Hamster, Mouse, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56940 Da |
| Antigen Region | 467-497 aa |
| Gene ID | 7360 |
|---|---|
| Other Names | UTP--glucose-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, UGPase, UGP2, UGP1 |
| Target/Specificity | This UGP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-497 amino acids from the C-terminal region of human UGP2. |
| Dilution | WB~~1:2000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UGP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UGP2 (HGNC:12527) |
|---|---|
| Function | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. |
| Cellular Location | Cytoplasm |
| Tissue Location | Highly expressed in various brain regions. Expressed in amygdala, anterior cingulate cortex, caudate, cerebellar hemisphere, cerebellum, cortex, frontal cortex, hippocampus, hypothalamus, nucleus accumbens, putamen, spinal cord and substantia nigra (PubMed:31820119). Also widely expressed among other tissues, including liver, heart, placenta, lung, kidney, pancreas and skeletal muscle (PubMed:8354390, PubMed:8631325). |
Provided below are standard protocols that you may find useful for product applications.
Background
UGP2 is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue,UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme.
References
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007) Wistow,G., (er) Mol. Vis. 8, 205-220 (2002) Chang,H.Y., Eur. J. Biochem. 236 (2), 723-728 (1996)
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