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F3 antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P13726 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 33068 Da |
| Gene ID | 2152 |
|---|---|
| Other Names | Tissue factor, TF, Coagulation factor III, Thromboplastin, CD142, F3 |
| Target/Specificity | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | F3 antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | F3 |
|---|---|
| Function | Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. |
| Cellular Location | [Isoform 1]: Membrane; Single-pass type I membrane protein |
| Tissue Location | Lung, placenta and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
References
Scarpati E.M.,et al.Biochemistry 26:5234-5238(1987).
Morrissey J.H.,et al.Cell 50:129-135(1987).
Spicer E.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5148-5152(1987).
Fisher K.L.,et al.Thromb. Res. 48:89-99(1987).
Mackman N.,et al.Biochemistry 28:1755-1762(1989).
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